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LEU APL - Pethema LPA2005 induction and consolidations 1, 2 and 3 followed by maintenance [over 70 years] [intermediate risk] >
LEU - Pethema LPA2005 induction [over 70 years] [intermediate risk]
This regimen is a component of LEU APL - Pethema LPA2005 induction and consolidations 1, 2 and 3 followed by maintenance [over 70 years] [intermediate risk]
Pethema LPA2005 [over 70 years] [intermediate risk] - Induction (LEU APL - Pethema LPA2005 induction and consolidations 1, 2 and 3 followed by maintenance [over 70 years] [intermediate risk])
Treatment Overview
Differentiation syndrome:
- Monitor closely for differentiation syndrome in the first 7 to 10 days of treatment.
- Prompt recognition is necessary and if syndrome develops treat promptly with high dose intravenous corticosteroids (dexamethasone 10 mg/m2 IV Q12H) for at least 3 days and until complete resolution of symptoms.
- Decision to withhold tretinoin should be only for severe cases or if lack of response to corticosteroid.
Continue Induction treatment with tretinoin until complete remission is achieved, or for a maximum of 90 days.
Cycle 1 - 90 days
Cycle length:
90
tretinoin:
- Teratogenic—Ensure pregnant women are not exposed to tretinoin. Consult prescribing information.
- Continue tretinoin until a complete remission is achieved, or for a maximum of 90 days.
Oral dexamethasone: Only for patients with a white cell count (WCC) greater than 5 x 109/L at presentation, may be omitted if WCC at presentation is lower.
Cycle details
Cycle 1 - 90 days
| Medication | Dose | Route | Days | Max Duration |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration | 1 to 90 | |
| IDArubicin * | 12 mg/m² | intravenous | 2, 4, 6 | 15 minutes |
| dexamethasone | 2.5 mg/m² Twice daily | oral administration | 1 to 15 |
tretinoin:
- Teratogenic—Ensure pregnant women are not exposed to tretinoin. Consult prescribing information.
- Continue tretinoin until a complete remission is achieved, or for a maximum of 90 days.
Oral dexamethasone: Only for patients with a white cell count (WCC) greater than 5 x 109/L at presentation, may be omitted if WCC at presentation is lower.
Full details
Cycle 1 - 90 days
Day: 1
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 2
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| IDArubicin * | 12 mg/m² | intravenous | 15 minutes |
Instructions:
Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration. |
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 3
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 4
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| IDArubicin * | 12 mg/m² | intravenous | 15 minutes |
Instructions:
Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration. |
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 5
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 6
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| IDArubicin * | 12 mg/m² | intravenous | 15 minutes |
Instructions:
Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration. |
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 7
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 8
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 9
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 10
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 11
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 12
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 13
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 14
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 15
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
|
| dexamethasone | 2.5 mg/m² Twice daily | oral administration |
Instructions:
Take with food. Only for patients with a WCC > 5 x 109/L at presentation. |
Day: 16
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 17
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 18
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 19
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 20
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 21
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 22
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 23
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 24
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 25
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 26
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 27
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 28
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 29
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 30
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 31
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 32
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 33
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 34
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 35
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 36
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 37
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 38
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 39
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 40
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 41
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 42
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 43
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 44
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 45
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 46
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 47
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 48
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 49
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 50
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 51
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 52
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 53
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 54
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 55
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 56
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 57
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 58
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 59
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 60
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 61
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 62
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 63
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 64
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 65
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 66
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 67
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 68
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 69
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 70
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 71
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 72
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 73
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 74
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 75
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 76
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 77
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 78
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 79
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 80
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 81
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 82
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 83
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 84
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 85
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 86
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 87
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 88
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 89
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Day: 90
| Medication | Dose | Route | Max duration | Details |
|---|---|---|---|---|
| tretinoin | 45 mg/m² Daily in divided doses | oral administration |
Instructions:
Additional details:
Daily in TWO divided doses.
|
Additional details
Section 1: Teratogenic effects
Ensure pregnant women are not exposed to tretinoin. Consult prescribing information.
Supportive Care Factors
| Factor | Value |
|---|---|
| Antifungal prophylaxis: | Routine antifungal prophylaxis recommended |
| Antiviral prophylaxis for herpes virus: | Routine antiviral prophylaxis recommended |
| Emetogenicity: | Variable |
| Gastroprotection: | Gastroprotection may be considered |
| Pneumocystis jirovecii pneumonia (PJP) prophylaxis: | Routine antibiotic prophylaxis may be considered |
| Tumour lysis syndrome prophylaxis: | Tumour lysis syndrome prophylaxis is recommended |
Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.
Emetogenicity:
- MEDIUM days 2, 4, and 6;
- MINIMAL to LOW (oral) days 1 to 90 (excluding 2, 4, and 6).
References
Pharmaco (NZ) Ltd Vesanoid® New Zealand data sheet 21 April 2022 https://www.medsafe.govt.nz/profs/datasheet/v/Vesanoidcap.pdf (accessed 15 July 2022).
* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.
s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.